Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Protein phosphatase PP2A regulatory subunit B | 0.0047 | 0.6842 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.11 | 0.11 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0062 | 0.9605 | 0.9246 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.9605 | 1 |
Brugia malayi | serine/threonine protein phosphatase 2A | 0.0047 | 0.6842 | 0.6842 |
Echinococcus granulosus | protein phosphatase pp2a regulatory subunit b | 0.0047 | 0.6842 | 0.3973 |
Leishmania major | protein phosphatase 2A regulatory subunit, putative | 0.0047 | 0.6842 | 1 |
Echinococcus granulosus | protein phosphatase 1b | 0.0056 | 0.8481 | 0.7101 |
Brugia malayi | hypothetical protein | 0.0062 | 0.9605 | 0.9605 |
Trichomonas vaginalis | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative | 0.0047 | 0.6842 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0017 | 0.11 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.6842 | 1 |
Trichomonas vaginalis | protein phosphatase PP2A regulatory subunit B, putative | 0.0047 | 0.6842 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0047 | 0.6842 | 1 |
Trypanosoma cruzi | protein phosphatase 2A regulatory subunit, putative | 0.0047 | 0.6842 | 1 |
Schistosoma mansoni | protein phosphatase 2C | 0.0056 | 0.8481 | 0.7101 |
Loa Loa (eye worm) | protein phosphatase 2C containing protein | 0.0064 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0047 | 0.6842 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0047 | 0.6842 | 1 |
Schistosoma mansoni | protein phosphatase pp2a regulatory subunit B | 0.0047 | 0.6842 | 0.3973 |
Echinococcus multilocularis | protein phosphatase pp2a regulatory subunit b | 0.0047 | 0.6842 | 0.3973 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.9605 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0017 | 0.11 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0036 | 0.476 | 0.476 |
Schistosoma mansoni | protein phosphatase 2C | 0.0064 | 1 | 1 |
Onchocerca volvulus | Protein phosphatase PP2A 55 kDa regulatory subunit homolog | 0.0047 | 0.6842 | 0.5 |
Trypanosoma cruzi | protein phosphatase 2A regulatory subunit, putative | 0.0047 | 0.6842 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.9605 | 1 |
Echinococcus multilocularis | protein phosphatase 1b | 0.0064 | 1 | 1 |
Trichomonas vaginalis | protein phosphatase pp2a regulatory subunit B, putative | 0.0047 | 0.6842 | 0.5 |
Echinococcus granulosus | protein phosphatase 1b | 0.0064 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0062 | 0.9605 | 0.9246 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0017 | 0.11 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.9605 | 1 |
Echinococcus multilocularis | protein phosphatase 1b | 0.0056 | 0.8481 | 0.7101 |
Loa Loa (eye worm) | serine/threonine protein phosphatase 2A | 0.0047 | 0.6842 | 0.6451 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0017 | 0.11 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0036 | 0.476 | 0.4112 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0062 | 0.9605 | 0.9246 |
Trypanosoma brucei | protein phosphatase 2A regulatory subunit, putative | 0.0047 | 0.6842 | 1 |
Schistosoma mansoni | protein phosphatase 2C | 0.0056 | 0.8481 | 0.7101 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.9605 | 0.9246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.