Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | thymidine kinase, putative | 0.0587 | 1 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.0587 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0123 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0123 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0173 | 0.1081 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0587 | 1 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0587 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0587 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0123 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0123 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0173 | 0.1081 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0123 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0173 | 0.1081 | 0.5 |
Onchocerca volvulus | 0.0123 | 0 | 0.5 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0123 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0123 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0587 | 1 | 0.5 |
Giardia lamblia | Thymidine kinase | 0.0587 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0587 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0123 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.