Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.1246 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.021 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1246 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1246 | 1 | 1 |
Onchocerca volvulus | 0.0694 | 0.4671 | 0.863 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1246 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1246 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1246 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1246 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.021 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0771 | 0.5413 | 0.5413 |
Loa Loa (eye worm) | hypothetical protein | 0.0771 | 0.5413 | 0.5413 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0771 | 0.5413 | 0.5413 |
Echinococcus granulosus | carboxylesterase 5A | 0.1246 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1246 | 1 | 1 |
Onchocerca volvulus | 0.0771 | 0.5413 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.021 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0771 | 0.5413 | 0.5413 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.021 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1246 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0771 | 0.5413 | 0.5413 |
Loa Loa (eye worm) | hypothetical protein | 0.1246 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 0.63 ug kg-1 | The compound was evaluated for hypotensive activity in anaesthetized Sprague Dawley rats on intravenous administration | ChEMBL. | 1433171 |
IC90 (functional) | = 1.6 uM | In vitro inhibitory concentration producing 90% reduction in maximum contraction produced by KCl (20 mmol) in isolated aorta of rat. | ChEMBL. | 1433171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.