Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor 2 | 0.0363 | 0.1046 | 0.1046 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0664 | 0.4658 | 0.4658 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0427 | 0.1811 | 0.2008 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0664 | 0.4658 | 0.4034 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1108 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0276 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0276 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0363 | 0.1046 | 0.1046 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0394 | 0.1414 | 0.1414 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0444 | 0.2024 | 0.2024 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0394 | 0.1414 | 0.1568 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1027 | 0.9022 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0363 | 0.1046 | 0.1046 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0394 | 0.1414 | 0.0412 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0276 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0751 | 0.5704 | 0.5704 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0363 | 0.1046 | 0.1046 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0363 | 0.1046 | 0.1046 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0276 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0751 | 0.5704 | 0.5202 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.2 uM | In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected KRP-297 cells | ChEMBL. | 12904063 |
EC50 (binding) | = 2.2 uM | Transactivation of human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 11738577 |
EC50 (functional) | = 2.2 uM | In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected KRP-297 cells | ChEMBL. | 12904063 |
EC50 (binding) | = 2.2 uM | Transactivation of human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 11738577 |
EC50 (functional) | = 3 uM | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor gamma expressed in KRP-297 cells | ChEMBL. | 12904063 |
EC50 (binding) | = 3 uM | Concentration of compound that affords half-maximum transactivation of human Peroxisome proliferator activated receptor gamma in CHO-K1 cells was determined in vitro | ChEMBL. | 11738577 |
EC50 (functional) | = 3 uM | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor gamma expressed in KRP-297 cells | ChEMBL. | 12904063 |
EC50 (binding) | = 3 uM | Concentration of compound that affords half-maximum transactivation of human Peroxisome proliferator activated receptor gamma in CHO-K1 cells was determined in vitro | ChEMBL. | 11738577 |
IA (functional) | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor delta expressed in CHO-K1 cells | ChEMBL. | 12904063 | |
IA (functional) | 0 | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor delta expressed in CHO-K1 cells | ChEMBL. | 12904063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.