Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0343 | 0.2548 | 0.5 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Onchocerca volvulus | 0.0483 | 0.6135 | 1 | |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Entamoeba histolytica | aldose reductase, putative | 0.0343 | 0.2548 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.6135 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 0.5 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.037 | 0.3236 | 1 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0483 | 0.6135 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Entamoeba histolytica | aldose reductase, putative | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0483 | 0.6135 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.037 | 0.3236 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0483 | 0.6135 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0343 | 0.2548 | 0.7876 |
Loa Loa (eye worm) | oxidoreductase | 0.0343 | 0.2548 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0483 | 0.6135 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0343 | 0.2548 | 0.2548 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0343 | 0.2548 | 0.2548 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0483 | 0.6135 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 73 nM | Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]-DADLE (1.3-2.0 nM) to rat brain membranes | ChEMBL. | 10479286 |
Ki (binding) | = 272 nM | Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U69,593 (1.2-2.2 nM) to guinea pig brain membranes | ChEMBL. | 10479286 |
Ki (binding) | = 308 nM | Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]-DAMGO (1.4-3 nM) to rat brain membranes | ChEMBL. | 10479286 |
Selectivity ratio (binding) | = 3.7 | Selectivity ratio of binding affinity towards kappa of guinea pig brain membrane to delta receptors of rat brain membranes | ChEMBL. | 10479286 |
Selectivity ratio (binding) | = 4.2 | Selectivity ratio of binding affinity towards mu to delta receptors of rat brain membranes | ChEMBL. | 10479286 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.