Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | References |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain. | ChEMBL. | 11020275 | |
Ki (binding) | Compound was tested for binding affinity against Cholecystokinin type A receptor receptor on guinea pig pancreatic membranes; Not determined | ChEMBL. | 11020275 | |
Ki (binding) | = 1460 nM | Binding affinity against cholecystokinin type B receptor on guinea pig cortex. | ChEMBL. | 11020275 |
Ki (binding) | = 1460 nM | Binding affinity against cholecystokinin type B receptor on guinea pig cortex. | ChEMBL. | 11020275 |
ND (binding) | 0 | Compound was tested for binding affinity against Cholecystokinin type A receptor receptor on guinea pig pancreatic membranes; Not determined | ChEMBL. | 11020275 |
ND (binding) | 0 | Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain. | ChEMBL. | 11020275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.