Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | carbonic anhydrase, putative | 0.1405 | 0.9508 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1405 | 0.9508 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.147 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0755 | 0.4601 | 0.7358 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1007 | 0.6498 | 1 |
Onchocerca volvulus | 0.0198 | 0.0397 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1007 | 0.6498 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1007 | 0.6498 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0459 | 0.2361 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1007 | 0.6498 | 0.5788 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1007 | 0.6498 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0198 | 0.0397 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1007 | 0.6498 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0944 | 0.6028 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1007 | 0.6498 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0459 | 0.2361 | 0.3634 |
Schistosoma mansoni | carbonic anhydrase | 0.1405 | 0.9508 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1007 | 0.6498 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0879 | 0.5536 | 0.9089 |
Echinococcus granulosus | carbonic anhydrase | 0.0459 | 0.2361 | 0.3634 |
Echinococcus multilocularis | carbonic anhydrase | 0.0459 | 0.2361 | 0.3634 |
Echinococcus granulosus | carbonic anhydrase II | 0.1007 | 0.6498 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1007 | 0.6498 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1007 | 0.6498 | 0.5788 |
Trichomonas vaginalis | conserved hypothetical protein | 0.147 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0459 | 0.2361 | 0.3634 |
Echinococcus multilocularis | carbonic anhydrase | 0.0459 | 0.2361 | 0.3634 |
Echinococcus granulosus | carbonic anhydrase | 0.0459 | 0.2361 | 0.3634 |
Plasmodium falciparum | carbonic anhydrase | 0.0459 | 0.2361 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1405 | 0.9508 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.3 nM | Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligand | ChEMBL. | 9733485 |
Ki (binding) | = 2.3 nM | Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligand | ChEMBL. | 9733485 |
Ki (binding) | = 2.8 nM | Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligand | ChEMBL. | 9733485 |
Ki (binding) | = 2.8 nM | Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligand | ChEMBL. | 9733485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.