Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0148 | 0.0311 | 0.0347 |
Brugia malayi | hypothetical protein | 0.0148 | 0.0311 | 0.0844 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0532 | 0.397 | 0.3777 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0532 | 0.397 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0148 | 0.0311 | 0.0844 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0148 | 0.0311 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.0148 | 0.0311 | 0.0975 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0153 | 0.036 | 0.1027 |
Entamoeba histolytica | aminopeptidase, putative | 0.0148 | 0.0311 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Echinococcus granulosus | aminopeptidase N | 0.0502 | 0.3686 | 0.9284 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0148 | 0.0311 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0148 | 0.0311 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0221 | 0.1011 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0148 | 0.0311 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0148 | 0.0311 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0148 | 0.0311 | 0.0347 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0148 | 0.0311 | 0.5 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0212 | 0.0921 | 0.0629 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0221 | 0.1011 | 0.3167 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0406 | 0.2773 | 0.869 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0221 | 0.1011 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0221 | 0.1011 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.3191 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0532 | 0.397 | 1 |
Onchocerca volvulus | 0.0502 | 0.3686 | 1 | |
Echinococcus multilocularis | aminopeptidase N | 0.0502 | 0.3686 | 0.9284 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0148 | 0.0311 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0221 | 0.1011 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0148 | 0.0311 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0221 | 0.1011 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0148 | 0.0311 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0148 | 0.0311 | 0.0783 |
Brugia malayi | Peptidase family M1 containing protein | 0.0502 | 0.3686 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0221 | 0.1011 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.2278 | 0.7139 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0221 | 0.1011 | 0.2742 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0153 | 0.036 | 0.1027 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0148 | 0.0311 | 0.0783 |
Onchocerca volvulus | 0.0148 | 0.0311 | 0.0074 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Intrinsic activity (binding) | = 1 | The compound was tested for intrinsic activity against 5-HT1D receptor | ChEMBL. | 7658443 |
Intrinsic activity (binding) | = 1 | The compound was tested for intrinsic activity against 5-HT1D receptor | ChEMBL. | 7658443 |
p[A50] (binding) | < 4.5 | The compound was tested for binding affinity against 5-HT2A receptor | ChEMBL. | 7658443 |
p[A50] (binding) | = 7 | The compound was tested for binding affinity against 5-HT1D receptor | ChEMBL. | 7658443 |
p[A50] (binding) | < 4.5 | The compound was tested for binding affinity against 5-HT2A receptor | ChEMBL. | 7658443 |
p[A50] (binding) | = 7 | The compound was tested for binding affinity against 5-HT1D receptor | ChEMBL. | 7658443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.