Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0233 | 0.059 | 0.2031 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0998 | 0.2694 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3313 | 0.9065 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.024 | 0.0222 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.0204 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3313 | 0.9065 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0054 | 0.0097 | 0.0048 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.024 | 0.0222 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0233 | 0.059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.059 | 0.7666 |
Onchocerca volvulus | 0.0291 | 0.0748 | 0.0556 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0233 | 0.059 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0998 | 0.2694 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0076 | 0.0026 |
Brugia malayi | SWIRM domain containing protein | 0.0233 | 0.059 | 0.0722 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0076 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.059 | 0.7666 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.059 | 0.7666 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.0273 | 0.0261 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0998 | 0.2694 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2655 | 0.7254 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.3079 | 0.8423 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0076 | 0.0062 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0998 | 0.2694 | 1 |
Schistosoma mansoni | amine oxidase | 0.0233 | 0.059 | 1 |
Brugia malayi | hypothetical protein | 0.0233 | 0.059 | 0.0722 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0076 | 0.0083 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.0204 | 0.0567 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0233 | 0.059 | 0.2031 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.024 | 0.0222 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0233 | 0.059 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0233 | 0.059 | 0.2191 |
Schistosoma mansoni | kinase | 0.0047 | 0.0078 | 0.0118 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.0204 | 0.2545 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0233 | 0.059 | 0.064 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.024 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.059 | 0.7666 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0998 | 0.2694 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.0273 | 0.0261 |
Echinococcus multilocularis | 0.0233 | 0.059 | 1 | |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0054 | 0.0097 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0076 | 0.0282 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0233 | 0.059 | 0.0595 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.0204 | 0.2545 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.0273 | 0.3557 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0204 | 0.0567 |
Schistosoma mansoni | amine oxidase | 0.0233 | 0.059 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0233 | 0.059 | 0.0595 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0076 | 0.0081 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0076 | 0.0083 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0998 | 0.2694 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0233 | 0.059 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0233 | 0.059 | 0.0595 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0233 | 0.059 | 0.0722 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0204 | 0.0567 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0076 | 0.0083 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0233 | 0.059 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0233 | 0.059 | 0.2031 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0233 | 0.059 | 1 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.0748 | 0.0941 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0076 | 0.0006 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0233 | 0.059 | 0.2031 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0076 | 0.0006 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.024 | 0.0222 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.0204 | 0.0184 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0204 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0076 | 0.0081 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0076 | 0.0083 |
Plasmodium vivax | hypothetical protein, conserved | 0.0233 | 0.059 | 0.2031 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0233 | 0.059 | 0.2191 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.024 | 0.2896 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0233 | 0.059 | 0.064 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0233 | 0.059 | 0.2031 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0233 | 0.059 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0233 | 0.059 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0076 | 0.0083 |
Giardia lamblia | Telomerase catalytic subunit | 0.0998 | 0.2694 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0233 | 0.059 | 0.2031 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.0204 | 0.0567 |
Treponema pallidum | DNA polymerase I (polA) | 0.0054 | 0.0097 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0054 | 0.0097 | 0.0052 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0233 | 0.059 | 0.2031 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.0273 | 0.0261 |
Plasmodium vivax | hypothetical protein, conserved | 0.0233 | 0.059 | 0.2031 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0076 | 0.0062 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.024 | 0.0222 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.0204 | 0.1951 |
Onchocerca volvulus | 0.0233 | 0.059 | 0.0394 | |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0998 | 0.2694 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.0204 | 0.2545 |
Leishmania major | UDP-galactopyranose mutase | 0.0233 | 0.059 | 0.2031 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.059 | 0.7666 |
Mycobacterium ulcerans | oxidoreductase | 0.0233 | 0.059 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.059 | 0.7666 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.0748 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0076 | 0.0083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.