Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0239 | 0.3402 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0239 | 0.3402 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0695 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0239 | 0.3402 | 1 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0004 | 0 | 0.5 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0004 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0695 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0239 | 0.3402 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.