Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.9857 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0045 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0045 | 1 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0026 | 0.2768 | 0.2768 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0026 | 0.2768 | 0.2808 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0026 | 0.2768 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0045 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0045 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0045 | 1 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0026 | 0.2768 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0045 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0045 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0026 | 0.2768 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0026 | 0.2768 | 0.2768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.9857 | 0.9857 |
Entamoeba histolytica | p21-activated kinase | 0.0045 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0045 | 1 | 1 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0026 | 0.2768 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0026 | 0.2768 | 0.2808 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | Inhibition of recombinant human histamine H1 receptor | ChEMBL. | 26191365 |
IC50 (binding) | = 6 nM | Inhibition of recombinant human muscarinic M1 receptor | ChEMBL. | 26191365 |
IC50 (binding) | = 12000 nM | Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH as substrate preincubated for 60 mins followed by substrate addition measured after 60 mins by Caliper assay | ChEMBL. | 26191365 |
IC50 (binding) | = 54 uM | Inhibition of wild type phosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH as substrate preincubated for 60 mins followed by substrate addition measured after 60 mins by Caliper assay | ChEMBL. | 26191365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.