Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0836 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0242 | 0.1723 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0269 | 0.2102 | 0.2102 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0269 | 0.2102 | 0.3743 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.2102 | 0.2102 |
Echinococcus granulosus | laminin | 0.0269 | 0.2102 | 0.2102 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0836 | 1 | 1 |
Loa Loa (eye worm) | AStacin protease | 0.0522 | 0.5631 | 0.5631 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0269 | 0.2102 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0521 | 0.5615 | 0.5615 |
Echinococcus multilocularis | laminin | 0.0269 | 0.2102 | 0.2102 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0521 | 0.5615 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0521 | 0.5615 | 0.5615 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0521 | 0.5615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1723 | 0.1723 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0521 | 0.5615 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0521 | 0.5615 | 0.5615 |
Loa Loa (eye worm) | hypothetical protein | 0.0802 | 0.9526 | 0.9526 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0836 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0521 | 0.5615 | 0.5615 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0521 | 0.5615 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0242 | 0.1723 | 0.3068 |
Plasmodium falciparum | carbonic anhydrase | 0.0119 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0521 | 0.5615 | 0.5615 |
Brugia malayi | Fibulin-1 precursor | 0.0269 | 0.2102 | 0.3743 |
Schistosoma mansoni | egf-like domain protein | 0.0242 | 0.1723 | 0.1723 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0521 | 0.5615 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0269 | 0.2102 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0521 | 0.5615 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1723 | 0.1723 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0521 | 0.5615 | 0.5615 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.309 | 0.309 |
Echinococcus multilocularis | fibrillin 1 | 0.0269 | 0.2102 | 0.2102 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0242 | 0.1723 | 0.1723 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibitory activity against Steroid sulfatase expressed in CHO cells | ChEMBL. | 14552755 |
IC50 (binding) | > 30 uM | Inhibitory activity against Steroid sulfatase expressed in CHO cells | ChEMBL. | 14552755 |
IC50 (binding) | > 100 uM | Inhibitory activity against purified human Steroid sulfatase | ChEMBL. | 14552755 |
IC50 (binding) | > 100 uM | Inhibitory activity against purified human Steroid sulfatase | ChEMBL. | 14552755 |
Ki (binding) | ND 0 uM | Inhibitory constant against purified human Steroid sulfatase; ND= not done | ChEMBL. | 14552755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.