Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Onchocerca volvulus | 0.0087 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in human MeWo cells xenografted athymic nude mouse assessed as mortality at 50 mg/kg, ip administered every other day of 21 days post tumor cell injection up to 48 days followed by administered 40 mg/kg, ip | ChEMBL. | 26190462 | |
Activity (ADMET) | Toxicity in human MeWo cells xenografted athymic nude mouse assessed as mortality at 50 mg/kg, ip administered every other day of 21 days post tumor cell injection measured on day 45 | ChEMBL. | 26190462 | |
Activity (ADMET) | Toxicity in human MeWo cells xenografted athymic nude mouse assessed as severe dehydration at 50 mg/kg, ip administered every other day of 21 days post tumor cell injection measured on day 45 | ChEMBL. | 26190462 | |
Activity (functional) | < 25 % | Cytotoxicity against human MeWo cells assessed as reduction of cell viability after 48 hrs by CellTiter-Blue assay | ChEMBL. | 26190462 |
IC50 (functional) | = 6.74 uM | Cytotoxicity against human SKOV3 cells after 48 hrs by CellTiter-Blue assay | ChEMBL. | 26190462 |
Inhibition (binding) | Inhibition of human ATX phosphodiesterase expressed in Sf9 cells assessed as hydrolysis of FS-3 preincubated for 2 mins before substrate addition measured after 5 to 25 mins by fluorescence assay | ChEMBL. | 26190462 | |
Inhibition (binding) | Irreversible inhibition of human ATX phosphodiesterase activity expressed in Sf9 cells assessed as hydrolysis of FS-3 preincubated for 2 mins before substrate addition measured 1000 fold dilution by fluorescence assay | ChEMBL. | 26190462 | |
Ki (binding) | = 3.5 uM | Inhibition of human ATX phosphodiesterase expressed in Sf9 cells assessed as hydrolysis of FS-3 measured after 5 to 25 mins by fluorescence assay | ChEMBL. | 26190462 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 26190462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.