Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0097 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | AUR protein kinase | 0.0127 | 0.0339 | 0.0587 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0127 | 0.0339 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0127 | 0.0339 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | 0.0192 | 0.0868 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0792 | 0.5771 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0127 | 0.0339 | 0.0587 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0153 | 0.0552 | 0.0552 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0097 | 0.0097 | 0.0097 |
Trypanosoma brucei | aurora B kinase | 0.0127 | 0.0339 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.0552 | 0.0803 |
Onchocerca volvulus | 0.0153 | 0.0552 | 0.5 | |
Leishmania major | protein kinase, putative | 0.0127 | 0.0339 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0127 | 0.0339 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0348 | 0.214 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0153 | 0.0552 | 0.0552 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0127 | 0.0339 | 0.0587 |
Entamoeba histolytica | protein kinase , putative | 0.0127 | 0.0339 | 0.5 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.131 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0127 | 0.0339 | 0.0339 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0127 | 0.0339 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0127 | 0.0339 | 0.0427 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0153 | 0.0552 | 0.0957 |
Giardia lamblia | Aurora kinase | 0.0127 | 0.0339 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0348 | 0.214 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0127 | 0.0339 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0097 | 0.0097 | 0.0097 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0127 | 0.0339 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0127 | 0.0339 | 0.0587 |
Brugia malayi | serine/threonine kinase 12 | 0.0127 | 0.0339 | 0.0587 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0153 | 0.0552 | 0.0957 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0192 | 0.0868 | 0.2937 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.131 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.0339 | 0.0427 |
Toxoplasma gondii | aurora kinase | 0.0127 | 0.0339 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0127 | 0.0339 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQI | 0.0192 | 0.0868 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0097 | 0.0167 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0127 | 0.0339 | 0.0339 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0192 | 0.0868 | 0.2937 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0097 | 0.0097 | 0.0097 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0792 | 0.5771 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0792 | 0.5771 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.0552 | 0.0803 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0192 | 0.0868 | 0.2937 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0127 | 0.0339 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0127 | 0.0339 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0127 | 0.0339 | 0.0339 |
Echinococcus granulosus | aurora kinase A | 0.0127 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | AUR protein kinase | 0.0127 | 0.0339 | 0.0587 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0153 | 0.0552 | 0.0552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Glycomer activity determined as growth inhibition of human glioblastoma LN18 cells | ChEMBL. | 12904064 |
IC50 (functional) | > 50 uM | Glycomer activity determined as growth inhibition of human glioblastoma LNZ308 cells | ChEMBL. | 12904064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.