Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Biotin--acetyl-CoA-carboxylase ligase | Starlite/ChEMBL | References |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.021 | 0 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.021 | 0 | 0.5 |
Schistosoma mansoni | biotin-protein ligase | 0.021 | 0 | 0.5 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.021 | 0 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.021 | 0 | 0.5 |
Chlamydia trachomatis | biotin synthetase | 0.021 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0429 | 0.9183 | 0.5 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.021 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.021 | 0 | 0.5 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0448 | 1 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.021 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.021 | 0 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.021 | 0 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 14.7 degrees C | Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli assessed as change in melting temperature measured across 10 to 85 degC with 1 min incubation per 0.5 degC increase by differential scanning fluorimetric analysis | ChEMBL. | 26299766 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay | ChEMBL. | 26299766 |
Kd (binding) | = 0.315 nM | Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysis | ChEMBL. | 26299766 |
MIC>90 (functional) | = 3.12 uM | Antibacterial activity against Mycobacterium tuberculosis H37Rv measured at 10 to 14 days by broth microdilution method | ChEMBL. | 26299766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.