Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | porcupine homolog (Drosophila) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00181 porcupine, putative | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Loa Loa (eye worm) | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Schistosoma mansoni | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Brugia malayi | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0299 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0299 | 1 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.0299 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 45 ml/min.kg | Intrinsic clearance in human liver microsomes at 1 uM incubated for 60 mins in presence of NADPH by LC-MS/MS method | ChEMBL. | 26455655 |
CL (ADMET) | = 440 ml/min.kg | Intrinsic clearance in mouse liver microsomes at 1 uM incubated for 60 mins in presence of NADPH by LC-MS/MS method | ChEMBL. | 26455655 |
IC50 (binding) | = 0.96 nM | Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as reduction in Wnt ligand-driven LEF/TCF-dependent transcriptional activity | ChEMBL. | 26455655 |
Inhibition (binding) | Inhibition of porcupine (unknown origin) expressed in HEK293T cells transfected with pLinbin- Wnt3A plasmid assessed as inhibition of Wnt3A secretion at 0.1 uM incubated for 48 hrs by Western blotting method | ChEMBL. | 26455655 | |
Inhibition (ADMET) | = 50 % | Inhibition of CYP3A4 in human liver microsomes at 10 uM pre-incubated for 10 mins before midazolam substrate and NADPH addition by LC-MS/MS method | ChEMBL. | 26455655 |
Inhibition (ADMET) | = 53 % | Inhibition of CYP2D6 in human liver microsomes at 10 uM pre-incubated for 10 mins before dextromethorphan substrate and NADPH addition by LC-MS/MS method | ChEMBL. | 26455655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.