Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.0195 | 1 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0195 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0179 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0195 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 96.9 ug.hr/ml | Decrease in plasma clearance of D-serine in CD1 mouse assessed as D-serine AUC (0 to 6 hrs) at 30 mg/kg, po (Rvb = 43.3 microg.hr/ml) | ChEMBL. | 26309148 |
IC50 (binding) | = 0.05 uM | Inhibition of recombinant human DAAO expressed in HEK cells using D-serine as substrate assessed as formation of alpha-keto acid, ammonia, hydrogen peroxidase after 20 mins by horseradish peroxidase/o-phenylenediamine-based assay | ChEMBL. | 26309148 |
Inhibition (binding) | Inhibition of recombinant human DAAO expressed in HEK cells in presence of 10 to 100 uM of FAD | ChEMBL. | 26309148 | |
Inhibition (binding) | <= 5 % | Inhibition of NMDA receptor agonist binding site (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Inhibition (binding) | <= 5 % | Inhibition of NMDA receptor phencyclidine binding site (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Inhibition (binding) | <= 5 % | Inhibition of NMDA receptor MK801 binding site (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Inhibition (binding) | <= 5 % | Inhibition of strychnine-sensitive glycine receptor (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Inhibition (binding) | <= 5 % | Inhibition of MAO-A (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Inhibition (binding) | <= 5 % | Inhibition of MAO-B (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Inhibition (binding) | = 22 % | Inhibition of NMDA receptor glycine binding site (unknown origin) at 10 uM relative to control | ChEMBL. | 26309148 |
Ki (binding) | = 60 nM | Competitive inhibition of recombinant human DAAO expressed in HEK cells by double reciprocal plot analysis in presence of D-serine | ChEMBL. | 26309148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.