Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0439 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.3518 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0102 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0439 | 0.0439 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.3518 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0439 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.3833 | 0.3833 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.4272 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0439 | 0.1028 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0439 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0439 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.3833 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0439 | 0.1145 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.3833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3202 | 0.3202 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0102 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.4272 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0439 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.3833 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 54 nM | Inhibition of ROMK (unknown origin) expressed in HEK293 cells by electrophysiology assay | ChEMBL. | 26191360 |
IC50 (binding) | = 0.046 uM | Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assay | ChEMBL. | 26191360 |
IC50 (binding) | = 0.09 uM | Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assay | ChEMBL. | 26191360 |
IC50 (binding) | = 10 uM | Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells | ChEMBL. | 26191360 |
IC50 (binding) | = 11 uM | Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells | ChEMBL. | 26191360 |
IC50 (binding) | = 14 uM | Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay | ChEMBL. | 26191360 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.