Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | serine-threonine protein kinase-like protein | 0.0004 | 0 | 0.5 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0239 | 0.3402 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0239 | 0.3402 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0239 | 0.3402 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0695 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0239 | 0.3402 | 1 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0695 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 68.2 % | Inhibition of human MDR1 transfected in mouse NIH/3T3 MDR1-G185 cells assessed as daunomycin accumulation at 10 uM after 30 mins by flow cytometry (Rvb = 13.2 +/- 1.1%) | ChEMBL. | 25695368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.