Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase | 0.0034 | 0.0399 | 0.0743 |
Echinococcus granulosus | carbonic anhydrase | 0.0034 | 0.0399 | 0.0743 |
Echinococcus multilocularis | carbonic anhydrase | 0.0034 | 0.0399 | 0.0743 |
Plasmodium falciparum | carbonic anhydrase | 0.0034 | 0.0399 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0147 | 0.5367 | 0.3919 |
Echinococcus granulosus | carbonic anhydrase | 0.0034 | 0.0399 | 0.0743 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.5367 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.2381 | 0.399 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0147 | 0.5367 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0147 | 0.5367 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0079 | 0.2381 | 0.4437 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0088 | 0.2793 | 0.5203 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0085 | 0.2631 | 0.4902 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0079 | 0.2381 | 0.4437 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0088 | 0.2793 | 0.5203 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0085 | 0.2631 | 0.4902 |
Echinococcus granulosus | carbonic anhydrase II | 0.0147 | 0.5367 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0253 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.5367 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0147 | 0.5367 | 1 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0079 | 0.2381 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.5367 | 0.3919 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0081 | 0.2461 | 0.4584 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0147 | 0.5367 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0105 | 0.3529 | 0.63 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0.0399 | 0.5 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0079 | 0.2381 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0034 | 0.0399 | 0.0743 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0079 | 0.2381 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0034 | 0.0399 | 0.0743 |
Trypanosoma brucei | squalene synthase, putative | 0.0253 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.5367 | 0.3919 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0147 | 0.5367 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2381 | 0.399 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0081 | 0.2461 | 0.4584 |
Trypanosoma cruzi | squalene synthase, putative | 0.0253 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = -0.96 | Calculated partition coefficient (clogP) (MlogP) | ChEMBL. | 12166932 |
IC50 (binding) | = 3.2 nM | Inhibitory activity against carbonic anhydrase II | ChEMBL. | 12166932 |
IC50 (binding) | = 3.2 nM | Inhibitory activity against carbonic anhydrase II | ChEMBL. | 12166932 |
Kd (binding) | = 0.13 nM | Dissociation constant was reported against Carbonic anhydrase II | ChEMBL. | 12166932 |
Kd (binding) | = 0.13 nM | Dissociation constant was reported against Carbonic anhydrase II | ChEMBL. | 12166932 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.