Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.021 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.021 | 0 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.021 | 0 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.021 | 0 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.021 | 0 | 0.5 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0448 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.021 | 0 | 0.5 |
Chlamydia trachomatis | biotin synthetase | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.021 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0429 | 0.9183 | 0.5 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.021 | 0 | 0.5 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Schistosoma mansoni | biotin-protein ligase | 0.021 | 0 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.021 | 0 | 0.5 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.021 | 0 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.