Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0307 | 1 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0307 | 1 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0307 | 1 | 1 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0307 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0307 | 1 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0307 | 1 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0307 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0307 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | Inhibition of mouse DGAT1 incubated for 60 mins using didecanoyl glycerol and [14C]decanoyl-CoA substrate by liquid scintillation counting and luminometry based flash plate assay | ChEMBL. | 26218650 |
IC50 (binding) | = 5 nM | Inhibition of human DGAT1 expressed in human Hep3B cells incubated for 60 mins using didecanoyl glycerol and [14C]decanoyl-CoA substrate by liquid scintillation counting and luminometry based flash plate assay | ChEMBL. | 26218650 |
IC50 (binding) | > 100 uM | Inhibition of human DGAT2 | ChEMBL. | 26218650 |
Inhibition (binding) | < 1 % | Inhibition of human ERG at 10 uM | ChEMBL. | 26218650 |
Inhibition (ADMET) | = 4.56 % | Inhibition of CYP1A2 (unknown origin) at 10 uM | ChEMBL. | 26218650 |
Inhibition (ADMET) | = 8.09 % | Inhibition of CYP2D6 (unknown origin) at 10 uM | ChEMBL. | 26218650 |
Inhibition (ADMET) | = 9.53 % | Inhibition of CYP2C19 (unknown origin) at 10 uM | ChEMBL. | 26218650 |
Inhibition (ADMET) | = 10.9 % | Inhibition of CYP3A4 (unknown origin) at 10 uM | ChEMBL. | 26218650 |
Inhibition (ADMET) | = 41.9 % | Inhibition of CYP2C9 (unknown origin) at 10 uM | ChEMBL. | 26218650 |
Inhibition (functional) | = 54 % | Reduction in glucose AUC in high fat diet fed diet-induced obesity mouse at 10 mg/kg, po administered daily for 4 weeks by oral glucose tolerance test | ChEMBL. | 26218650 |
Stabilty (ADMET) | > 99 % | Stability in human liver microsomes assessed as parent compound remaining after 30 mins | ChEMBL. | 26218650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.