Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase seto7 | 0.0079 | 0.5 | 0.5 |
Plasmodium falciparum | SET domain protein, putative | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Echinococcus multilocularis | histone lysine n methyltransferase setd8 | 0.0079 | 0.5 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET8 | 0.0079 | 0.5 | 0.5 |
Echinococcus granulosus | histone lysine n methyltransferase setd8 | 0.0079 | 0.5 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0079 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 48 uM | Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to biotinylated H4 (1 to 24) peptide substrate by scintillation proximity assay | ChEMBL. | 25554733 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.