Detailed view for EgrG_001031500

Basic information

TDR Targets ID: 580583
Echinococcus granulosus, histone lysine n methyltransferase setd8
Source Database / ID:  GeneDB

pI: 10.5127 | Length (AA): 359 | MW (Da): 39554 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0018024   histone-lysine N-methyltransferase activity  
GO:0005515   protein binding  

Metabolic Pathways

Lysine degradation (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
202 358 3f9x (A) 196 351 50.00 0 1 1.07613 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130816)

Species Accession Gene Product
Babesia bovis BBOV_IV004680   SET domain containing protein
Brugia malayi Bm1_00260   Protein set-1
Caenorhabditis elegans CELE_T26A5.7   Protein SET-1, isoform B
Cryptosporidium hominis Chro.40051   SET domain
Cryptosporidium parvum cgd4_370   protein with a SET domain within carboxy region
Drosophila melanogaster Dmel_CG3307   CG3307 gene product from transcript CG3307-RB
Echinococcus granulosus EgrG_001031500   histone lysine n methyltransferase setd8
Echinococcus multilocularis EmuJ_001031500   histone lysine n methyltransferase setd8
Homo sapiens ENSG00000183955   SET domain containing (lysine methyltransferase) 8
Loa Loa (eye worm) LOAG_02341   hypothetical protein
Mus musculus ENSMUSG00000049327   SET domain containing (lysine methyltransferase) 8
Neospora caninum NCLIV_011360   SET domain-containing protein, putative
Plasmodium berghei PBANKA_1001600   SET domain protein, putative
Plasmodium falciparum PF3D7_0403900   SET domain protein, putative
Plasmodium knowlesi PKNH_0301900   SET domain protein, putative
Plasmodium vivax PVX_001050   SET domain protein, putative
Plasmodium yoelii PY01349   SET domain, putative
Schistosoma japonicum Sjp_0109250   IPR001214,SET,domain-containing
Schistosoma japonicum Sjp_0018990   Histone-lysine N-methyltransferase SETD8, putative
Schistosoma mansoni Smp_055310   histone-lysine n-methyltransferase seto7
Schmidtea mediterranea mk4.004321.01   SETD8-1
Toxoplasma gondii TGME49_211730   histone lysine methyltransferase SET8
Theileria parva TP01_0281   hypothetical protein

Essentiality

EgrG_001031500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T26A5.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_T26A5.7 Caenorhabditis elegans larval arrest wormbase
CELE_T26A5.7 Caenorhabditis elegans larval lethal wormbase
CELE_T26A5.7 Caenorhabditis elegans slow growth wormbase
PBANKA_1001600 Plasmodium berghei Slow plasmo
TGME49_211730 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SET domain containing (lysine methyltransferase) 8 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0403 1 1
0.0403 1 1
0.0079 0.5 0.5
0.0193 0.2616 0.2616
0.0589 0.4049 0.8223
0.0548 0.743 1
0.0394 0.8214 1
0.0146 1 1
0.0391 0.76 0.76
0.0578 0.3861 1
0.0579 0.7829 1
0.0496 0.5854 0.6666
0.0588 0.295 1
0.0573 0.3891 0.8506
0.0385 0.5 0.5
0.0579 0.3373 1
0.0391 0.76 0.76
0.0079 0.5 0.5
0.0193 0.4031 0.4031
0.0079 0.5 0.5
0.0401 1 1
0.0583 0.395 1
0.0079 0.5 0.5
0.0479 0.5 0.5
0.0417 0.7389 1
0.0404 0.3283 1
0.0063 0.4053 0.8478
0.0561 0.8186 0.8186
0.0605 1 1
0.0548 0.743 1
0.0565 0.7066 0.8036
0.0473 0.2915 0.6957
0.0417 0.6888 1
0.0473 0.2915 0.6957
0.0399 0.5423 0.5755
0.0064 0.2983 1
0.0371 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_001031500 (Echinococcus granulosus), histone lysine n methyltransferase setd8
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