Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Anopheles gambiae | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 737 aa | 636 aa | 24.2 % |
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 737 aa | 616 aa | 27.3 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 737 aa | 650 aa | 34.5 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 737 aa | 651 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0205 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.29 nM | Inhibition of recombinant Anopheles gambiae wild type AChE after 60 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 2.47 nM | Inhibition of recombinant Anopheles gambiae wild type AChE after 10 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 6.47 nM | Inhibition of recombinant human AChE after 10 mins by Ellman assay | ChEMBL. | 26386602 |
IC50 (binding) | = 8.84 nM | Inhibition of recombinant human AChE after 60 mins by Ellman assay | ChEMBL. | 26386602 |
Inhibition (binding) | Inhibition of recombinant Anopheles gambiae wild type AChE by Ellman assay | ChEMBL. | 26386602 | |
Inhibition (binding) | Inhibition of recombinant human AChE by Ellman assay | ChEMBL. | 26386602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.