Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0171 | 0.0861 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0159 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0159 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0299 | 1 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0159 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0159 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0159 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0159 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Ability to inhibit hypoxanthine-guanine phosphoribosyltransferase in crude extracts of H.Ep.-2 cells. | ChEMBL. | 6991691 | |
Activity (functional) | Activity against P. berghei in mice. | ChEMBL. | 6991691 | |
Activity (functional) | Not significant 0 | Activity against P. berghei in mice. | ChEMBL. | 6991691 |
Activity (binding) | NI 0 | Ability to inhibit hypoxanthine-guanine phosphoribosyltransferase in crude extracts of H.Ep.-2 cells. | ChEMBL. | 6991691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.