Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0132 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0781 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.0514 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0132 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0781 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0132 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0514 | 0.0514 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0514 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0514 | 0.0514 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0132 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0781 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0781 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0781 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0514 | 0.0514 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.0514 | 0.0514 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.0514 | 0.0514 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0514 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0781 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0514 | 0.5 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0781 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0781 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0514 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0781 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0132 | 0 | 0.5 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0781 | 1 | 1 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 nM | Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR) | ChEMBL. | 8246233 |
IC50 (binding) | = 30 nM | Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR) | ChEMBL. | 8246233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.