Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Beta-galactosidase | References | |
Homo sapiens | galactosidase, beta 1 | References | |
Escherichia coli | beta-D-galactosidase | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | beta-galactosidase | 0.0282 | 0.3946 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0282 | 0.3946 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0282 | 0.3946 | 0.5 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0134 | 0 | 0.5 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0316 | 0.4849 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Induction of beta-galactosidase R201C mutant activity in GM1-gangliosidosis patient skin fibroblasts using 4-MU beta-gal substrate incubated for 96 hrs by fluorescence assay | ChEMBL. | 26838810 | |
FC (binding) | = 6 | Induction of beta-galactosidase R201C mutant activity in GM1-gangliosidosis patient skin fibroblasts at 0.04 uM using 4-MU beta-gal substrate incubated for 96 hrs by fluorescence assay relative to control | ChEMBL. | 26838810 |
FC (binding) | = 11 | Induction of beta-galactosidase R201C mutant activity in GM1-gangliosidosis patient skin fibroblasts at 25 uM using 4-MU beta-gal substrate incubated for 96 hrs by fluorescence assay relative to control | ChEMBL. | 26838810 |
FC (binding) | = 15 | Induction of beta-galactosidase R201C mutant activity in GM1-gangliosidosis patient skin fibroblasts at 5 uM using 4-MU beta-gal substrate incubated for 96 hrs by fluorescence assay relative to control | ChEMBL. | 26838810 |
IC50 (binding) | = 0.21 uM | Inhibition of human lysosomal beta-galactosidase using 4-MU beta-gal as substrate incubated for 96 hrs by fluorescence assay | ChEMBL. | 26838810 |
Ki (binding) | > 2 mM | Inhibition of human recombinant lysosomal alpha-galactosidase using 2,4-dinitrophenyl-alpha-D-galactopyranoside as substrate preincubated up to 5 mins followed by substrate addition measured up to 10 mins | ChEMBL. | 26838810 |
Ki (binding) | = 0.0029 uM | Inhibition of Escherichia coli lacZ beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside as substrate preincubated up to 5 mins followed by substrate addition measured up to 10 mins | ChEMBL. | 26838810 |
Ki (binding) | = 0.0127 uM | Inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside as substrate preincubated up to 5 mins followed by substrate addition measured up to 10 mins | ChEMBL. | 26838810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.