Detailed view for EmuJ_000741700

Basic information

TDR Targets ID: 965008
Echinococcus multilocularis, beta galactosidase
Source Database / ID:  GeneDB

pI: 5.1068 | Length (AA): 679 | MW (Da): 76206 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01301   Glycosyl hydrolases family 35

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0004565   beta-galactosidase activity  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
72 676 3d3a (A) 24 608 35.00 0 1 1.31012 -0.5
73 676 3thd (A) 29 643 42.00 0 1 1.39154 -0.66
78 246 5gsl (A) 6 194 42.00 0 1 0.735595 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128163)

Species Accession Gene Product
Arabidopsis thaliana AT1G72990   beta-galactosidase 17
Caenorhabditis elegans CELE_T19B10.3   Protein T19B10.3
Dictyostelium discoideum DDB_G0290217   glycoside hydrolase family 35 protein
Drosophila melanogaster Dmel_CG9092   beta galactosidase
Drosophila melanogaster Dmel_CG3132   Ectoderm-expressed 3
Echinococcus granulosus EgrG_000741700   beta galactosidase
Echinococcus multilocularis EmuJ_000741700   beta galactosidase
Homo sapiens ENSG00000166105   galactosidase, beta 1-like 3
Homo sapiens ENSG00000170266   galactosidase, beta 1
Homo sapiens ENSG00000163521   galactosidase, beta 1-like
Homo sapiens ENSG00000149328   galactosidase, beta 1-like 2
Loa Loa (eye worm) LOAG_15493   hypothetical protein
Loa Loa (eye worm) LOAG_11223   hypothetical protein
Mus musculus ENSMUSG00000036395   galactosidase, beta 1-like 2
Mus musculus ENSMUSG00000045594   galactosidase, beta 1
Mus musculus ENSMUSG00000026200   galactosidase, beta 1-like
Mus musculus ENSMUSG00000079644   predicted gene 1110
Mus musculus ENSMUSG00000031966   galactosidase, beta 1 like 3
Oryza sativa 4339457   Os05g0539400
Schistosoma japonicum Sjp_0309200   ko:K01190 beta-galactosidase [EC3.2.1.23], putative
Schistosoma japonicum Sjp_0072010   Beta-galactosidase precursor, putative
Schistosoma mansoni Smp_011990   beta-galactosidase
Schmidtea mediterranea mk4.007400.04   Beta-galactosidase
Schmidtea mediterranea mk4.004037.00   Beta-galactosidase
Schmidtea mediterranea mk4.007103.02  
Schmidtea mediterranea mk4.013240.00  
Schmidtea mediterranea mk4.007103.03   Beta-galactosidase
Schmidtea mediterranea mk4.007772.00   Beta-galactosidase
Schmidtea mediterranea mk4.014404.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Beta-galactosidase Compounds References
Homo sapiens galactosidase, beta 1 Compounds References
Bos taurus Beta-galactosidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0169 1 1
0.048 0.4637 1
0.0429 0.3876 0.3806
0.0282 0.5393 0.8136
0.0646 0.2598 0.2592
0.0113 0.3017 1
0.009 0.2836 1
0.0098 0.2931 0.4308
0.0642 0.3623 0.3617
0.0642 0.3623 0.3617
0.0145 1 1
0.064 0.4896 0.7621
0.0113 0.3017 1
0.0099 0.292 0.4141
0.0093 0.2922 0.4633
0.0095 0.2923 0.4772
0.0465 1 1
0.0382 0.3538 0
0.0281 0.5 0.5
0.0747 0.3349 0.3514
0.0092 0.2952 0.4939
0.0113 0.3017 1
0.0632 0.4354 1
0.0522 0.3474 0.6694
0.0396 1 1
0.0282 0.3946 0.5
0.0624 0.4081 1
0.0644 0.4122 1
0.063 0.4087 0.2281
0.0169 1 1
0.0874 0.3589 0.3589
0.0642 0.3623 0.3617
0.016 0.3963 0.3394
0.01 0.293 0.4292
0.0747 0.3349 0.3514
0.038 0.3904 0
0.0091 0.2873 0.499
0.009 0.2873 0.4993
0.1008 0.3048 0.3048
0.0515 0.4625 0
0.0901 0.3317 0.3317
0.0332 0.2902 0.279
0.0368 0.5077 0.4971
0.0874 0.3589 0.3589
0.0093 0.2952 0.4935
0.0642 0.3623 0.3617
0.0465 1 1
0.0898 0.3403 0.3403
0.0094 0.2912 0.4732
0.0093 0.2561 1
0.0475 0.3437 0.6632
0.0642 0.3623 0.3617
0.0277 0.3732 1
0.0631 0.4098 1
0.0321 0.3335 0.3335
0.0282 0.5393 0.8136
0.0282 0.3946 0.5
0.0642 0.3623 0.3617
0.0277 0.3732 1
0.0332 0.2902 0.279
0.0875 0.4538 0.4538
0.0522 0.3474 0.6694
0.0135 0.3954 0.3954
0.0423 0.2968 1
0.0092 0.2932 0.4639
0.0626 0.4091 1
0.0169 1 1
0.0091 0.2931 1
0.0186 0.2561 0.2765
0.0467 1 1
0.0096 0.2834 0.4927
0.0642 0.3623 0.3617
0.0626 0.4566 0.7495
0.0306 0.5 0.5
0.0169 0.5 0.5
0.0638 0.4363 1
0.0531 0.3485 1
0.0554 0.4213 0.4213
0.0626 0.4566 0.7495
0.0137 0.2996 0.2517
0.0646 0.4585 1
0.0626 0.4566 0.7495
0.0363 0.2975 0.4023
0.0186 0.2561 0.2765
0.0646 0.4585 1
0.0874 0.3589 0.3589
0.0626 0.4566 0.7495
0.048 1 1
0.0094 0.2912 0.4732
0.0094 0.2849 1
0.0091 0.2913 0.4514
0.0602 0.3656 1
0.044 1 1
0.0129 0.3408 0.6795
0.0745 0.2664 0.2661
0.0155 0.5521 1
0.0942 0.3329 0.3305
0.0629 0.4733 1
0.0475 0.3437 0.6632
0.038 0.3904 0
0.0321 0.3335 0.3335
0.0602 0.3656 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EmuJ_000741700 (Echinococcus multilocularis), beta galactosidase
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