Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | valosin containing protein | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0032 | 0.9326 | 0.9122 |
Mycobacterium ulcerans | ATPase | 0.002 | 0.4742 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.002 | 0.4584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.4584 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0034 | 1 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0032 | 0.9326 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0034 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.002 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0032 | 0.9326 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0034 | 1 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0032 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.002 | 0.4742 | 0.0000097958 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0034 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0032 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0034 | 1 | 1 |
Giardia lamblia | AAA family ATPase | 0.002 | 0.4742 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.002 | 0.4584 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0032 | 0.9326 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0032 | 0.9326 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0032 | 0.9326 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.002 | 0.4742 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of p97 ATPase in human A549 cells assessed as reduction in p62 protein incubated for 6 hrs by immunofluorescence assay | ChEMBL. | 26565666 | |
IC50 (binding) | = 0.815 uM | Inhibition of human p97 ATPase incubated for 15 mins by ADP Glo luminescence assay | ChEMBL. | 26565666 |
IC50 (binding) | = 6.14 uM | Inhibition of p97 ATPase in human A549 cells assessed as accumulation of K48 poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence assay | ChEMBL. | 26565666 |
IC50 (binding) | = 6.61 uM | Inhibition of p97 ATPase in human A549 cells assessed as accumulation of CHOP poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence assay | ChEMBL. | 26565666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.