Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Onchocerca volvulus | 0.0087 | 1 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.1195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity | Toxicity in Balb-c nu/nu mouse at 100 mg/kg, po bid administered for 5 days | LITERATURE. | 27780639 | |
EC50 (binding) | = 0.025 uM | Inhibition of human recombinant ATX/LPC 18 | LITERATURE. | 27780639 |
IC50 (binding) | = 0.001 uM | Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase substrate by horseradish peroxidase/choline oxidase-coupled assay | LITERATURE. | 27780639 |
IC50 (binding) | = 0.014 uM | Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horseradish peroxidase/choline oxidase-coupled assay | LITERATURE. | 27780639 |
IC50 (binding) | = 0.038 uM | Inhibition of ATX in human plasma assessed as decrease in LPA C18 | LITERATURE. | 27780639 |
Inhibition (binding) | Inhibition of human recombinant ATX/LPC 18 | LITERATURE. | 27780639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.