Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | wd40 repeat | 0.0075 | 0.0843 | 0.0843 |
Echinococcus granulosus | protein will die slowly | 0.0418 | 1 | 1 |
Echinococcus multilocularis | protein will die slowly | 0.0418 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0418 | 1 | 1 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0075 | 0.0843 | 0.0843 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0418 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0075 | 0.0843 | 0.0843 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0843 | 0.0843 |
Echinococcus granulosus | wd40 repeat | 0.0075 | 0.0843 | 0.0843 |
Onchocerca volvulus | 0.0418 | 1 | 0.5 | |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0075 | 0.0843 | 0.0843 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0075 | 0.0843 | 0.0843 |
Plasmodium falciparum | SPRY domain, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0418 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of post-glutamyl peptide hydrolyzing activity of human 20S proteasome at 50 uM using Cbz-Leu-Leu-Glu-AMC as substrate measured for 10 mins by fluorescence assay relative to control | LITERATURE. | 27318981 | |
Inhibition (binding) | = 18 % | Inhibition of chymotrypsin-like activity of human 20S proteasome at 50 uM using Suc-Leu-Leu-Val-Tyr-AMC as substrate measured for 10 mins by fluorescence assay relative to control | LITERATURE. | 27318981 |
Inhibition (binding) | = 33 % | Inhibition of trypsin-like activity of human 20S proteasome at 50 uM using Boc-Leu-Arg-Arg-AMC as substrate measured for 10 mins by fluorescence assay relative to control | LITERATURE. | 27318981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.