Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.1978 | 0.5446 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0042 | 0.0037 | 0.0053 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Plasmodium vivax | hypothetical protein, conserved | 0.0494 | 0.1301 | 1 |
Toxoplasma gondii | GAF domain-containing protein | 0.0494 | 0.1301 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0494 | 0.1301 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0685 | 0.1833 | 0.6628 |
Toxoplasma gondii | hypothetical protein | 0.0494 | 0.1301 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0685 | 0.1833 | 0.6628 |
Brugia malayi | Variant SH3 domain containing protein | 0.0036 | 0.0022 | 0.0022 |
Plasmodium falciparum | GAF domain-related protein, putative | 0.0494 | 0.1301 | 1 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.3608 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0685 | 0.1833 | 0.4867 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.4867 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0042 | 0.0037 | 0.0053 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0685 | 0.1833 | 0.1833 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Leishmania major | cAMP-specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0191 | 0.0453 | 0.0453 |
Schistosoma mansoni | DNA topoisomerase type I | 0.043 | 0.1122 | 0.1122 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.043 | 0.1122 | 0.4024 |
Mycobacterium leprae | conserved hypothetical protein | 0.0494 | 0.1301 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Giardia lamblia | hypothetical protein | 0.0191 | 0.0453 | 0.5 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Loa Loa (eye worm) | hypothetical protein | 0.3608 | 1 | 1 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.1787 | 0.4913 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1978 | 0.5446 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0494 | 0.1301 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0036 | 0.0022 | 0.0022 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0191 | 0.0453 | 0.0453 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0191 | 0.0453 | 0.5 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1484 | 0.4065 | 0.7235 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.1015 | 0.2755 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.1978 | 0.5446 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.1301 | 0.1301 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0036 | 0.0022 | 0.0022 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0685 | 0.1833 | 0.1833 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1978 | 0.5446 | 1 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus granulosus | c src tyrosine kinase | 0.0042 | 0.0037 | 0.0053 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0322 | 0.082 | 0.1805 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1484 | 0.4065 | 0.7235 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Schistosoma mansoni | tyrosine kinase | 0.0997 | 0.2705 | 0.2705 |
Schistosoma mansoni | adapter molecule crk | 0.0036 | 0.0022 | 0.0022 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | SRC-1 | 0.0042 | 0.0037 | 0.0037 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0697 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Brugia malayi | Variant SH3 domain containing protein | 0.0036 | 0.0022 | 0.0022 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0453 | 0.0453 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0191 | 0.0453 | 0.0697 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1293 | 0.3533 | 0.6179 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0191 | 0.0453 | 0.0697 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.1293 | 0.3533 | 1 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Giardia lamblia | Hypothetical protein | 0.0191 | 0.0453 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | PDE1B protein | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0042 | 0.0037 | 0.0053 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Leishmania major | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | nck2/grb4 | 0.0036 | 0.0022 | 0.0022 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0685 | 0.1833 | 0.6628 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0322 | 0.082 | 0.082 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Plasmodium vivax | topoisomerase I, putative | 0.043 | 0.1122 | 0.7888 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0685 | 0.1833 | 0.4867 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0453 | 0.0453 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0685 | 0.1833 | 0.6628 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0191 | 0.0453 | 0.0453 |
Leishmania major | hypothetical protein, conserved | 0.1293 | 0.3533 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0322 | 0.082 | 0.1805 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.1293 | 0.3533 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0042 | 0.0037 | 0.0037 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.4867 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0036 | 0.0022 | 0.0022 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.043 | 0.1122 | 0.7888 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.1293 | 0.3533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.4867 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0036 | 0.0022 | 0.0022 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Brugia malayi | SRC-1 | 0.0042 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Brugia malayi | DNA topoisomerase I | 0.043 | 0.1122 | 0.1122 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0042 | 0.0037 | 0.0053 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.043 | 0.1122 | 0.4024 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.043 | 0.1122 | 0.1122 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0322 | 0.082 | 0.082 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0042 | 0.0037 | 0.0053 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0042 | 0.0037 | 0.0037 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.1015 | 0.2755 | 1 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.1787 | 0.4913 | 1 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0322 | 0.082 | 0.1805 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Plasmodium falciparum | topoisomerase I | 0.043 | 0.1122 | 0.7888 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 95.3 mg kg-1 | Antiepileptic activity in po dosed KM mouse assessed as protection against maximal electroshock-induced seizures administered 1 hr prior to electrical stimulation | ChEMBL. | 26716755 |
Inhibition (functional) | = 60 % | Antiepileptic activity in KM mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, po administered 1 hr prior to electrical stimulation | ChEMBL. | 26716755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.