Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibitory activity of compound against human recombinant DNA topoisomerase I mediated DNA cleavage; No data | ChEMBL. | 11020283 | |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human lung HOP-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human colon HCT-116 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human CNS SF-539 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human melanoma UACC-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human ovarian OVCAR-3 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human renal SN12C cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human Prostate DU-145 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human breast MDA-MB-435 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human lung HOP-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human colon HCT-116 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human CNS SF-539 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human melanoma UACC-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human ovarian OVCAR-3 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human renal SN12C cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human Prostate DU-145 cell line | ChEMBL. | 11020283 |
GI50 (functional) | > 100 uM | Antiproliferative activity was determined for 50% growth inhibition against human breast MDA-MB-435 cell line | ChEMBL. | 11020283 |
MGM (functional) | = 76.1 | Mean graph midpoint for growth inhibition of all human cancer cell lines | ChEMBL. | 11020283 |
ND (binding) | 0 | Inhibitory activity of compound against human recombinant DNA topoisomerase I mediated DNA cleavage; No data | ChEMBL. | 11020283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.