Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | No references | |
Homo sapiens | prolyl endopeptidase | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.3882 | 0.3759 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.2526 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.3882 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.3882 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.3882 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1647 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.2526 | 0.632 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 130 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 610 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.