TDR Targets

Basic information

Technical information

TDR Targets ID: 212835
Name: 1-methyl-4-[10-(1-methylquinolin-1-ium-4-yl)d ecyl]quinolin-1-ium
MW: 426.636 | Formula: C30H38N2++
H donors: 0 H acceptors: 0 LogP: 9.27 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: C[n+]1ccc(c2c1cccc2)CCCCCCCCCCc1cc[n+](c2c1cccc2)C
InChi: 1S/C30H38N2/c1-31-23-21-25(27-17-11-13-19-29(27)31)15-9-7-5-3-4-6-8-10-16-26-22-24-32(2)30-20-14-12-18-28(26)30/h11-14,17-24H,3-10,15-16H2,1-2H3/q+2
InChiKey: CLCKXRNZWOZHBG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-methyl-4-[10-(1-methyl-4-quinolin-1-iumyl)decyl]quinolin-1-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	calcium-activated potassium channel	0.0181	0.2901	0.5852
Schistosoma mansoni	opsin-like receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1141	0.0905
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Schistosoma mansoni	hypothetical protein	0.0174	0.2771	0.5569
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	G protein coupled receptor 139	0.0111	0.1466	0.3527
Echinococcus granulosus	neuropeptide receptor A26	0.0111	0.1466	0.3527
Brugia malayi	ORL1-like opioid receptor	0.0111	0.1466	0.1291
Echinococcus multilocularis	small conductance calcium activated potassium	0.019	0.3092	0.6367
Schistosoma mansoni	myosin xvIII	0.0111	0.1466	0.2742
Brugia malayi	Serotonin receptor	0.0111	0.1466	0.1291
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0074	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0111	0.1466	0.1291
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Schistosoma mansoni	neuropeptide receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0085	0.094	0.0698
Echinococcus granulosus	serotonin receptor	0.0111	0.1466	0.3527
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0111	0.1466	0.3527
Onchocerca volvulus		0.0111	0.1466	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	somatostatin receptor	0.0111	0.1466	0.3527
Brugia malayi	RE15519p	0.0111	0.1466	0.1291
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Schistosoma mansoni	amine GPCR	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0235	0.402	0.386
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0111	0.1466	0.2742
Schistosoma mansoni	biogenic amine receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0111	0.1466	0.3527
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0111	0.1466	0.1238
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0074	0.5
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Schistosoma mansoni	hypothetical protein	0.0111	0.1466	0.2742
Echinococcus granulosus	tm gpcr rhodopsin	0.0111	0.1466	0.3527
Brugia malayi	hypothetical protein	0.0122	0.169	0.1519
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Echinococcus granulosus	g-protein coupled receptor	0.0111	0.1466	0.3527
Brugia malayi	larval opioid receptor	0.0111	0.1466	0.1291
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0111	0.1466	0.3527
Echinococcus granulosus	neuropeptide receptor	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0111	0.1466	0.1291
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0111	0.1466	0.3527
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Schistosoma mansoni	neuropeptide F-like receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0192	0.3127	0.2944
Loa Loa (eye worm)	G-protein coupled receptor	0.0111	0.1466	0.1238
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0148	0.222	0.2954
Schistosoma mansoni	opsin-like receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Onchocerca volvulus		0.0111	0.1466	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	glutaminase	0.0274	0.4815	0.4677
Echinococcus granulosus	biogenic amine 5HT receptor	0.0235	0.402	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0111	0.1466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Onchocerca volvulus		0.0111	0.1466	0.5
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Brugia malayi	Melatonin receptor type 1A	0.0111	0.1466	0.1291
Echinococcus multilocularis	geminin	0.0174	0.2771	0.511
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Onchocerca volvulus		0.0111	0.1466	0.5
Schistosoma mansoni	hypothetical protein	0.019	0.3092	0.6265
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Brugia malayi	hypoxia-induced factor 1	0.0153	0.2338	0.2181
Loa Loa (eye worm)	G-protein coupled receptor	0.0111	0.1466	0.1238
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0	0.5
Schistosoma mansoni	hypothetical protein	0.0111	0.1466	0.2742
Schistosoma mansoni	histamine h1 receptor	0.0111	0.1466	0.2742
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Brugia malayi	G protein-coupled receptor	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Schistosoma mansoni	biogenic amine receptor	0.0111	0.1466	0.2742
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	glutaminase	0.0274	0.4815	1
Echinococcus granulosus	orexin receptor type 2	0.0111	0.1466	0.3527
Brugia malayi	sulfakinin receptor protein	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	biogenic amine receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0526	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Leishmania major	C-8 sterol isomerase-like protein	0.0375	0.6902	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	amine GPCR	0.0111	0.1466	0.2742
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0375	0.6902	0.6839
Trichomonas vaginalis	glutaminase, putative	0.0274	0.4815	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	neuropeptide Y receptor	0.0111	0.1466	0.3527
Brugia malayi	neuropeptide F receptor	0.0111	0.1466	0.1291
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0111	0.1466	0.3527
Loa Loa (eye worm)	neuropeptide F receptor	0.0111	0.1466	0.1238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Echinococcus granulosus	geminin	0.0174	0.2771	0.6834
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0143	0.2135	0.5223
Echinococcus granulosus	fmrfamide receptor	0.0111	0.1466	0.3527
Echinococcus multilocularis	serotonin receptor	0.0235	0.402	1
Onchocerca volvulus		0.0111	0.1466	0.5
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0074	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0111	0.1466	0.3527
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Echinococcus granulosus	g protein coupled receptor	0.0111	0.1466	0.3527
Brugia malayi	Serotonin receptor	0.0111	0.1466	0.1291
Brugia malayi	G-protein coupled receptor	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	small conductance calcium activated potassium	0.019	0.3092	0.7648
Echinococcus granulosus	hypothetical protein	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	7tm_1 domain containing protein	0.0111	0.1466	0.3527
Schistosoma mansoni	calcium-activated potassium channel	0.019	0.3092	0.6265
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	neuropeptide receptor	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	acetyltransferase	0.0148	0.222	0.2012
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	tm gpcr rhodopsin	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0153	0.2338	0.2133
Echinococcus granulosus	7TM GPCR rhodopsin	0.0111	0.1466	0.3527
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0375	0.6902	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Brugia malayi	putative neuropeptide receptor NPR1	0.0111	0.1466	0.1291
Loa Loa (eye worm)	glutaminase 2	0.0274	0.4815	0.4677
Onchocerca volvulus		0.0111	0.1466	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0111	0.1466	0.2742
Brugia malayi	putative neuropeptide receptor	0.0111	0.1466	0.1291
Brugia malayi	Dopamine receptor	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0166	0.2603	0.2405
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0375	0.6902	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	amine GPCR	0.0111	0.1466	0.2742
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0111	0.1466	0.1291
Echinococcus granulosus	neuropeptide s receptor	0.0111	0.1466	0.3527
Schistosoma mansoni	adenoreceptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Schistosoma mansoni	opsin-like receptor	0.0111	0.1466	0.2742
Onchocerca volvulus		0.0111	0.1466	0.5
Onchocerca volvulus		0.0111	0.1466	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0111	0.1466	0.3527
Schistosoma mansoni	hypothetical protein	0.0174	0.2771	0.5569
Echinococcus granulosus	tm gpcr rhodopsin	0.0111	0.1466	0.3527
Schistosoma mansoni	amine GPCR	0.0111	0.1466	0.2742
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0111	0.1466	0.1291
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0111	0.1466	0.1238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	g protein coupled receptor	0.0111	0.1466	0.3527
Echinococcus granulosus	g protein coupled receptor	0.0111	0.1466	0.3527
Onchocerca volvulus		0.0111	0.1466	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0111	0.1466	0.3527
Brugia malayi	hypothetical protein	0.0166	0.2603	0.2452
Brugia malayi	glutaminase DH11.1	0.0274	0.4815	0.4709
Brugia malayi	AKH receptor	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	melatonin receptor type 1A	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0318	0.572	0.5605
Onchocerca volvulus		0.0111	0.1466	0.5
Onchocerca volvulus		0.0111	0.1466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.1466	0.2742
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0111	0.1466	0.1238
Loa Loa (eye worm)	neuropeptide F receptor	0.0111	0.1466	0.1238
Schistosoma mansoni	neuropeptide receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	sex peptide receptor	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Brugia malayi	Cytochrome P450 family protein	0.0052	0.026	0.0061
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0111	0.1466	0.1291
Schistosoma mansoni	growth hormone secretagogue receptor	0.0111	0.1466	0.2742
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0111	0.1466	0.2742
Onchocerca volvulus		0.0111	0.1466	0.5
Brugia malayi	Dopamine receptor protein 2	0.0111	0.1466	0.1291
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0235	0.402	0.8276
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Schistosoma mansoni	neuropeptide receptor	0.0111	0.1466	0.2742
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0148	0.222	0.4376
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Mycobacterium ulcerans	glutaminase	0.0274	0.4815	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0111	0.1466	0.1238
Echinococcus granulosus	neuropeptide FF receptor 2	0.0111	0.1466	0.3527
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0111	0.1466	0.1238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Brugia malayi	acetyltransferase, GNAT family protein	0.0148	0.222	0.2061
Onchocerca volvulus		0.0111	0.1466	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0111	0.1466	0.3527
Schistosoma mansoni	hypothetical protein	0.0111	0.1466	0.2742
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0111	0.1466	0.2742
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	dro:myosuppressin receptor	0.0111	0.1466	0.3527
Onchocerca volvulus		0.0111	0.1466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0375	0.6902	0.682
Loa Loa (eye worm)	hypothetical protein	0.019	0.3092	0.2907
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus granulosus	biogenic amine 5HT receptor	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0111	0.1466	0.5
Brugia malayi	neuropeptide F receptor	0.0111	0.1466	0.1291
Schistosoma mansoni	hypothetical protein	0.0052	0.0247	0.0099
Brugia malayi	G-protein coupled receptor	0.0111	0.1466	0.1291
Onchocerca volvulus		0.0111	0.1466	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0111	0.1466	0.3527
Onchocerca volvulus		0.0111	0.1466	0.5
Brugia malayi	GnHR receptor homolog	0.0111	0.1466	0.1291
Schistosoma mansoni	neuropeptide F-like receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	neuropeptides capa receptor	0.0111	0.1466	0.3527
Brugia malayi	follicle stimulating hormone receptor	0.0111	0.1466	0.1291
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0111	0.1466	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Schistosoma mansoni	neuropeptide receptor	0.0111	0.1466	0.2742
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0235	0.402	0.386
Brugia malayi	hypothetical protein	0.0111	0.1466	0.1291
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0111	0.1466	0.2742
Echinococcus granulosus	allatostatin A receptor	0.0111	0.1466	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238
Echinococcus multilocularis	serotonin receptor	0.0235	0.402	1
Schistosoma mansoni	amine GPCR	0.0111	0.1466	0.2742
Schistosoma mansoni	hypothetical protein	0.0111	0.1466	0.2742
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0111	0.1466	0.2742
Onchocerca volvulus		0.0111	0.1466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1466	0.1238

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 40 uM	SKCa-blocking activity of the compound was determined by its ability to inhibit after hyperpolarization (AHP) in cultured rat sympathetic neurons	ChEMBL.	8558503
IC50 (functional)	= 40 uM	SKCa-blocking activity of the compound was determined by its ability to inhibit after hyperpolarization (AHP) in cultured rat sympathetic neurons	ChEMBL.	8558503
Ratio (functional)	= 26	Equieffective molar ratio of compound to inhibit hyperpolarization in cultured rat sympathetic neurons	ChEMBL.	8558503

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 10532571

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 212835