Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic kainate 2 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, kainate 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Glutamate receptor 2 precursor | glutamate receptor, ionotropic, kainate 2 | 892 aa | 839 aa | 31.8 % |
Onchocerca volvulus | Glutamate receptor ionotropic kainate 2 | 908 aa | 849 aa | 32.0 % | |
Drosophila melanogaster | Glutamate receptor IA | Glutamate receptor ionotropic kainate 2 | 908 aa | 907 aa | 35.3 % |
Drosophila melanogaster | Glutamate receptor IIB | Glutamate receptor ionotropic kainate 2 | 908 aa | 868 aa | 29.6 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate receptor ionotropic kainate 2 | 908 aa | 884 aa | 22.9 % |
Onchocerca volvulus | Putative 39S ribosomal protein L45, mitochondrial | Glutamate receptor ionotropic kainate 2 | 908 aa | 836 aa | 32.9 % |
Echinococcus multilocularis | glutamate receptor 2 | Glutamate receptor ionotropic kainate 2 | 908 aa | 846 aa | 30.0 % |
Echinococcus granulosus | glutamate receptor 2 | Glutamate receptor ionotropic kainate 2 | 908 aa | 846 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0097 | 0.4883 | 0.4883 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0072 | 0.231 | 0.154 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0072 | 0.231 | 0.231 |
Echinococcus multilocularis | NMDA receptor | 0.0097 | 0.4883 | 0.4883 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0061 | 0.1126 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0072 | 0.231 | 0.231 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0147 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0135 | 0.8816 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0061 | 0.1126 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0147 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0097 | 0.4883 | 0.4883 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0147 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0097 | 0.4883 | 0.4883 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0061 | 0.1126 | 0.1126 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0061 | 0.1126 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0061 | 0.1126 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0147 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0135 | 0.8816 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0147 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0072 | 0.231 | 0.231 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0061 | 0.1126 | 0.1126 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0072 | 0.231 | 0.231 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0061 | 0.1126 | 0.1126 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0097 | 0.4883 | 0.4883 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.8 nM | Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Ki (binding) | = 2.8 nM | Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Ki (binding) | = 146.6 nM | Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Ki (binding) | = 146.6 nM | Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Response (functional) | = 33 % | Electrophysiological activity at 1 microM domoate from HEK293 cells transfected with ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Response (functional) | = 33 % | Electrophysiological activity at 1 microM domoate from HEK293 cells transfected with ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Response (functional) | = 86 % | Electrophysiological activity at 10 microM domoate from HEK293 cells transfected with Ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Response (functional) | = 86 % | Electrophysiological activity at 10 microM domoate from HEK293 cells transfected with Ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Response (functional) | = 99 % | Electrophysiological activity at 30 microM domoate from HEK293 cells transfected with ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Response (functional) | = 99 % | Electrophysiological activity at 30 microM domoate from HEK293 cells transfected with ionotropic glutamate receptor kainate 2 | ChEMBL. | 8809152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.