Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | ectonucleotide pyrophosphatase/phosphodiesterase 2 | References | |
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | References | |
Rattus norvegicus | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1195 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0262 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Onchocerca volvulus | 0.0262 | 1 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0121 | 0.1195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.01 nM | Inhibition of human ATX using FS3 as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assay | ChEMBL. | 26745766 |
IC50 (binding) | > 100 nM | Inhibition of human ATX using lysophosphatidylcholine as substrate preincubated with enzyme followed by substrate addition measured after 30 mins by luminescence assay | ChEMBL. | 26745766 |
IC50 (binding) | = 100 nM | Inhibition of ATX in human plasma assessed as inhibition of LPA production after 2 hrs by LC-MS/MS analysis | ChEMBL. | 26745766 |
IC50 (binding) | = 131 nM | Inhibition of recombinant human ATX using lysophosphatidylcholine as substrate by choline release assay | ChEMBL. | 26745766 |
IC50 (binding) | = 224 nM | Inhibition of recombinant mouse ATX using lysophosphatidylcholine as substrate by choline release assay | ChEMBL. | 26745766 |
IC50 (binding) | >= 500 nM | Inhibition of ATX in rat plasma assessed as inhibition of LPA production after 2 hrs by LC-MS/MS analysis | ChEMBL. | 26745766 |
IC50 (binding) | >= 500 nM | Inhibition of ATX in mouse plasma assessed as inhibition of LPA production after 2 hrs by LC-MS/MS analysis | ChEMBL. | 26745766 |
Inhibition (binding) | = 90 % | Inhibition of ATX in human plasma assessed as inhibition of LPA 18:2 production after 2 hrs by LC-MS/MS analysis relative to control | ChEMBL. | 26745766 |
T1/2 (ADMET) | = 5 hr | Half life in human | ChEMBL. | 26745766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.