Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1358 | 0.1358 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0155 | 0.3891 | 0.3965 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0238 | 0.695 | 0.695 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0322 | 1 | 1 |
Schistosoma mansoni | integrin alpha | 0.0155 | 0.3891 | 0.3378 |
Schistosoma mansoni | hypothetical protein | 0.0322 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0322 | 1 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0317 | 0.9812 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.1374 | 0.14 |
Echinococcus multilocularis | integrin alpha 3 | 0.0119 | 0.2572 | 0.1949 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0205 | 0.5729 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.2515 | 0.2515 |
Schistosoma mansoni | integrin beta subunit | 0.0187 | 0.5055 | 0.464 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0117 | 0.2515 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2677 | 0.2677 |
Echinococcus multilocularis | integrin beta 2 | 0.0235 | 0.6813 | 0.6546 |
Echinococcus granulosus | integrin beta 2 | 0.0235 | 0.6813 | 0.6546 |
Echinococcus granulosus | integrin alpha 3 | 0.0119 | 0.2572 | 0.1949 |
Loa Loa (eye worm) | integrin beta-2 | 0.0317 | 0.9812 | 0.9812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.07 uM | Tested in vitro for cytotoxicity against human tumor cell line UACC 62 (melanoma) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.07 uM | Tested in vitro for cytotoxicity against human tumor cell line UACC 62 (melanoma) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.4 uM | Tested in vitro for cytotoxicity against human tumor cell line MCF-7/ADR (breast) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.4 uM | Tested in vitro for cytotoxicity against human tumor cell line ACHN (renal). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.4 uM | Tested in vitro for cytotoxicity against human tumor cell line MCF-7/ADR (breast) | ChEMBL. | 10714502 |
GI50 (functional) | = 0.4 uM | Tested in vitro for cytotoxicity against human tumor cell line ACHN (renal). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.5 uM | Tested in vitro for cytotoxicity against human tumor cell line OVCAR8 (ovarian). | ChEMBL. | 10714502 |
GI50 (functional) | = 0.5 uM | Tested in vitro for cytotoxicity against human tumor cell line OVCAR8 (ovarian). | ChEMBL. | 10714502 |
GI50 (functional) | = 1 uM | Tested in vitro for cytotoxicity against human tumor cell line DU-145 (prostate) | ChEMBL. | 10714502 |
GI50 (functional) | = 1 uM | Tested in vitro for cytotoxicity against human tumor cell line DU-145 (prostate) | ChEMBL. | 10714502 |
GI50 (functional) | = 2 uM | Tested in vitro for cytotoxicity against human tumor cell line SF-268 (CNS). | ChEMBL. | 10714502 |
GI50 (functional) | = 2 uM | Tested in vitro for cytotoxicity against human tumor cell line HOP62 (lung) | ChEMBL. | 10714502 |
GI50 (functional) | = 2 uM | Tested in vitro for cytotoxicity against human tumor cell line SF-268 (CNS). | ChEMBL. | 10714502 |
GI50 (functional) | = 2 uM | Tested in vitro for cytotoxicity against human tumor cell line HOP62 (lung) | ChEMBL. | 10714502 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.