Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | diacylglycerol lipase, alpha | References | |
Homo sapiens | abhydrolase domain containing 6 | References | |
Mus musculus | abhydrolase domain containing 6 | References | |
Homo sapiens | diacylglycerol lipase, alpha | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | epoxide hydrolase 1 | abhydrolase domain containing 6 | 337 aa | 275 aa | 21.4 % |
Plasmodium falciparum | epoxide hydrolase 2 | abhydrolase domain containing 6 | 336 aa | 295 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0346 | 0.3339 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0346 | 0.3339 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0346 | 0.3339 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0346 | 0.3339 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0346 | 0.3339 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0346 | 0.3339 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0346 | 0.3339 | 0.5 |
Onchocerca volvulus | 0.0346 | 0.3339 | 0.5 | |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0998 | 0.9918 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0346 | 0.3339 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0346 | 0.3339 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0346 | 0.3339 | 0.5 |
Brugia malayi | Lipase family protein | 0.0346 | 0.3339 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of MB064 probe binding to ABHD6 in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after 20 mins by gel-based competitive activity based protein profiling assay | LITERATURE. | 27992221 |
IC50 (binding) | = 5.6 | Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assay | LITERATURE. | 27992221 |
IC50 (binding) | = 7.1 | Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after 20 mins by gel-based competitive activity based protein profiling assay | LITERATURE. | 27992221 |
IC50 (binding) | = 7.7 | Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay | LITERATURE. | 27992221 |
Inhibition (binding) | Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after 20 mins by gel-based competitive activity based protein profiling assay | LITERATURE. | 27992221 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.