Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | coagulation factor XI | References | |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References | |
Homo sapiens | protease, serine, 3 | References | |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | coagulation factor X | References | |
Homo sapiens | coagulation factor II (thrombin) | References | |
Homo sapiens | kallikrein 1 | References | |
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Brugia malayi | Trypsin family protein | kallikrein 1 | 262 aa | 247 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | PAN domain-containing protein | 0.0356 | 0.9732 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.0356 | 0.9732 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0363 | 1 | 0.5 |
Onchocerca volvulus | 0.0363 | 1 | 1 | |
Onchocerca volvulus | 0.0319 | 0.8343 | 0.8343 | |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0363 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4 nM | Inhibition of purified human tissue kallikrein 1 using H-D-Val-Leu-Arg-AFC as substrate | ChEMBL. | 27015008 |
Ki (binding) | = 1450 nM | Inhibition of recombinant human Tissue factor/factor 7a using S2288 as substrate after 30 to 60 mins | ChEMBL. | 27015008 |
Ki (binding) | > 6200 nM | Inhibition of purified human trypsin after 30 to 60 mins | ChEMBL. | 27015008 |
Ki (binding) | = 6800 nM | Inhibition of purified human factor 10a using S2765 as substrate after 30 to 60 mins | ChEMBL. | 27015008 |
Ki (binding) | = 7400 nM | Inhibition of purified human thrombin after 30 to 60 mins | ChEMBL. | 27015008 |
Ki (binding) | > 11000 nM | Inhibition of purified human factor 11a after 30 to 60 mins | ChEMBL. | 27015008 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.