Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | perforin-like protein 2 | 0.003 | 0.5305 | 1 |
Echinococcus multilocularis | macrophage expressed protein | 0.003 | 0.5305 | 1 |
Plasmodium falciparum | perforin-like protein 4 | 0.003 | 0.5305 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.003 | 0.5305 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0018 | 0 | 0.5 |
Plasmodium vivax | perforin-like protein 3 | 0.003 | 0.5305 | 1 |
Plasmodium vivax | perforin-like protein 4 | 0.003 | 0.5305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | macrophage expressed protein | 0.003 | 0.5305 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.5305 | 0.5305 |
Plasmodium vivax | perforin-like protein 5 | 0.003 | 0.5305 | 1 |
Plasmodium vivax | perforin-like protein 1 | 0.003 | 0.5305 | 1 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.003 | 0.5305 | 1 |
Chlamydia trachomatis | hypothetical protein | 0.003 | 0.5305 | 0.5 |
Plasmodium falciparum | perforin-like protein 1 | 0.003 | 0.5305 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | perforin-like protein 3 | 0.003 | 0.5305 | 1 |
Plasmodium falciparum | perforin-like protein 5 | 0.003 | 0.5305 | 1 |
Plasmodium vivax | perforin-like protein 2 | 0.003 | 0.5305 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Brugia malayi | Kringle domain containing protein | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity | Toxicity in NIH Swiss mouse erythrocytes assessed as hemolytic activity up to 500 uM incubated for 60 mins | LITERATURE. | 27560386 | |
Activity | Cytotoxicity in mouse GLUTag cells assessed as effect on plasma membrane integrity through LDH release up to 1 uM after 20 mins in presence of glucose by nonradioactive CytoTox96 assay | LITERATURE. | 27560386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.