Detailed view for PVX_099575

Basic information

TDR Targets ID: 265766
Plasmodium vivax, perforin-like protein 3
Source Database / ID:  PlasmoDB 

pI: 7.0056 | Length (AA): 783 | MW (Da): 87832 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01823   MAC/Perforin domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
79 124 4v2a (A) 242 288 17.00 0.31 0.02 0.261148 -0.71
187 538 4e0s (B) 148 508 27.00 0.00016 0.82 0.395853 1.08
187 538 4a5w (B) 169 529 28.00 0.000016 0.47 0.357853 1.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_134280)

Species Accession Gene Product
Babesia bovis BBOV_II007150   mac/perforin domain containing protein
Babesia bovis BBOV_IV001370   MAC/perforin domain containing protein
Dictyostelium discoideum DDB_G0287265   hypothetical protein
Neospora caninum NCLIV_034870   MAC/Perforin domain containing protein, related
Neospora caninum NCLIV_020990   hypothetical protein
Plasmodium berghei PBANKA_1006300   perforin-like protein 1
Plasmodium berghei PBANKA_0824200   perforin-like protein 3
Plasmodium falciparum PF3D7_0408700   perforin-like protein 1
Plasmodium falciparum PF3D7_0923300   perforin-like protein 3
Plasmodium knowlesi PKNH_0306700   perforin-like protein 1
Plasmodium knowlesi PKNH_0721300   perforin-like protein 3
Plasmodium vivax PVX_000810   perforin-like protein 1
Plasmodium vivax PVX_099575   perforin-like protein 3
Plasmodium yoelii PY05180   MAC/Perforin domain, putative
Plasmodium yoelii PY00454   MAC/Perforin domain, putative
Toxoplasma gondii TGME49_204130   perforin-like protein PLP1
Toxoplasma gondii TGME49_272430   MAC/Perforin domain-containing protein
Theileria parva TP01_0164   hypothetical protein
Theileria parva TP02_0166   hypothetical protein

Essentiality

PVX_099575 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0824200 Plasmodium berghei Dispensable plasmo
PBANKA_1006300 Plasmodium berghei Dispensable plasmo
TGME49_272430 Toxoplasma gondii Probably non-essential sidik
TGME49_204130 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.003 0.5305 1
0.0175 0.4943 1
0.0053 1 1
0.0185 1 1
0.0212 0.4318 1
0.0208 0.3903 0.5
0.0045 1 1
0.0127 0.744 1
0.0217 0.4392 1
0.0121 0.3049 1
0.0208 0.3903 0.5
0.0081 0.4635 1
0.0022 0.3918 0.5
0.0009 0.5 0.5
0.0231 0.6527 1
0.0217 0.4392 1
0.004 0.5 0.5
0.0009 0.5 0.5
0.0061 1 0.5
0.0009 0.5 0.5
0.0227 1 1
0.0009 0.5 0.5
0.0181 0.2781 0.5
0.0199 0.5 0.5
0.0023 0.2782 0
0.003 0.5305 1
0.0055 0.3362 0.5
0.0199 0.5 0.5
0.0143 0.3796 1
0.0094 0.5443 1
0.0009 0.5 0.5
0.0153 1 1
0.0175 1 1
0.0174 0.4917 1
0.0281 1 1
0.0009 0.5 0.5
0.029 0.5 0.5
0.021464 0.5 0.5
0.0108 1 1
0.0087 0.4303 1
0.0231 0.6527 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PVX_099575 (Plasmodium vivax), perforin-like protein 3
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