Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0663 | 0.0974 | 0.5293 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0663 | 0.0974 | 0.5293 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0663 | 0.0974 | 0.5293 |
Echinococcus granulosus | glutamate receptor 2 | 0.0663 | 0.0974 | 0.5293 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0524 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0663 | 0.0974 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0779 | 0.1791 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0779 | 0.1791 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0663 | 0.0974 | 0.5293 |
Chlamydia trachomatis | glutamine binding protein | 0.0524 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1945 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0663 | 0.0974 | 0.5293 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1945 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0524 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0524 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1945 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0663 | 0.0974 | 0.5293 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0663 | 0.0974 | 0.5293 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0779 | 0.1791 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0524 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0663 | 0.0974 | 0.5293 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0524 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0663 | 0.0974 | 0.5293 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (functional) | = 5.8 M | Cytotoxic activity of the compound against P-388 cell line | ChEMBL. | 15203159 |
-Log IC50 (functional) | = 5.8 M | Cytotoxic activity of the compound against A-549 cell line | ChEMBL. | 15203159 |
-Log IC50 (functional) | = 5.8 M | Cytotoxic activity of the compound against HT-29 cell line | ChEMBL. | 15203159 |
-Log IC50 (functional) | = 5.8 M | Cytotoxic activity of the compound against MEL-28 cell line | ChEMBL. | 15203159 |
-Log IC50 (functional) | = 5.8 M | Cytotoxic activity of the compound against H116 cell line | ChEMBL. | 15203159 |
IC50 (functional) | = 5.8 | Cytotoxic activity of the compound against P-388 cell line | ChEMBL. | 15203159 |
IC50 (functional) | = 5.8 | Cytotoxic activity of the compound against A-549 cell line | ChEMBL. | 15203159 |
IC50 (functional) | = 5.8 | Cytotoxic activity of the compound against HT-29 cell line | ChEMBL. | 15203159 |
IC50 (functional) | = 5.8 | Cytotoxic activity of the compound against MEL-28 cell line | ChEMBL. | 15203159 |
IC50 (functional) | = 5.8 | Cytotoxic activity of the compound against H116 cell line | ChEMBL. | 15203159 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15203159 | |
Homo sapiens | ChEMBL23 | 15203159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.