Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | PAS domain containing serine/threonine kinase | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131169 | All targets in OG5_131169 | |
Candida albicans | similar to S. cerevisiae PAS domain-containing Serine/threonine Kinase | Get druggable targets OG5_131169 | All targets in OG5_131169 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | Get druggable targets OG5_131169 | All targets in OG5_131169 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0082 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0082 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0082 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0082 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0082 | 1 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0082 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Onchocerca volvulus | 0.0055 | 0.648 | 0.5 | |
Entamoeba histolytica | casein kinase, putative | 0.0082 | 1 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0082 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0082 | 1 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0082 | 1 | 0.5 |
Plasmodium vivax | unspecified product | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | <= 10 uM | Inhibition of N-terminal GST-tagged human recombinant PASK kinase domain (879 to 1323 residues) expressed in insect cells using MBP protein substrate incubated for 120 mins in presence of [33P]ATP by scintillation counting based radiochemical assay | PATENT. | No reference |
IC50 (binding) | <= 10 uM | Inhibition of human recombinant PASK using Ulight-peptide substrate incubated for 2 hrs by TR-FRET assay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.