Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | No references | |
Rattus norvegicus | Sodium/hydrogen exchanger 3 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0199 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0199 | 1 | 0.5 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0199 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0199 | 1 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0199 | 1 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0199 | 1 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0199 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0199 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0199 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0199 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0199 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0199 | 1 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0199 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | NHE-3 | 0.0199 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0199 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0199 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0199 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.8 | Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated in NH4Cl-HEPES buffer containing BCECF-AM dye followed by washout with ammonium free HEPES and subsequent addition of compound in presence of NHE1 antagonist EIPA by fluorescence assay | PATENT. | No reference |
IC50 (binding) | = 8.4 | Inhibition of rat NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated in NH4Cl-HEPES buffer containing BCECF-AM dye followed by washout with ammonium free HEPES and subsequent addition of compound in presence of NHE1 antagonist EIPA by fluorescence assay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.