Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 3 | References | |
Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 1 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | glucose transporter, putative | solute carrier family 2 (facilitated glucose transporter), member 1 | 492 aa | 395 aa | 23.5 % |
Trypanosoma brucei | THT1 - hexose transporter, putative | solute carrier family 2 (facilitated glucose transporter), member 3 | 496 aa | 442 aa | 23.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glucose transport protein | 0.012 | 1 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.012 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.012 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.012 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.012 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.012 | 1 | 0.5 |
Plasmodium vivax | hexose transporter | 0.012 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.012 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.012 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.012 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human GLUT2 expressed in CHO cells assessed as ATP production co-incubated with 30 mM fructose for 16 hrs by CellTiter-Glo assay in presence of oxidative phosphorylation inhibitor rotenone | ChEMBL. | 26949183 | |
IC50 (binding) | = 0.47 uM | Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in presence of oxidative phosphorylation inhibitor rotenone | ChEMBL. | 26949183 |
IC50 (binding) | = 1.2 uM | Inhibition of human GLUT3 expressed in GLUT1 knock-out DLD1 cells assessed as ATP production co-incubated with 300 mM glucose for 16 hrs by CellTiter-Glo assay in presence of oxidative phosphorylation inhibitor rotenone | ChEMBL. | 26949183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.