Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1836 | 0.2179 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.046 | 0.0545 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0841 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0712 | 0.8428 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0712 | 0.8428 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.046 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.046 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.1202 | 0.113 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1836 | 0.2179 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.046 | 0.5 |
Echinococcus multilocularis | geminin | 0.0175 | 0.1836 | 0.2102 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.046 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.046 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.1202 | 0.113 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0032 | 0.0082 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.046 | 0.0452 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.046 | 0.0452 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0712 | 0.8428 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0032 | 0.0082 | 0.0097 |
Echinococcus granulosus | geminin | 0.0175 | 0.1836 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0082 | 0.0097 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.046 | 0.0545 |
Onchocerca volvulus | 0.0032 | 0.0082 | 0.5 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.1202 | 0.113 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC0.01 (functional) | = 1.5 uM/A unit/min | Polymerizing activity of microtubule protein against the twice cycled microtubule protein | ChEMBL. | 9733497 |
IC50 (functional) | = 0.48 nM | Relative resistance was measured against human paclitaxel-resistant cell lines | ChEMBL. | 9733497 |
IC50 (functional) | = 0.48 nM | Relative resistance was measured against human paclitaxel-resistant cell lines | ChEMBL. | 9733497 |
IC50 (functional) | = 1 nM | Cytotoxic activity against was measured human Burkitt lymphoma cell lines. | ChEMBL. | 9733497 |
IC50 (functional) | = 1.9 nM | Cytotoxic activity was measured against human colon carcinoma cell lines | ChEMBL. | 9733497 |
IC50 (functional) | = 1.9 nM | Cytotoxic activity was measured against human colon carcinoma cell lines | ChEMBL. | 9733497 |
IC50 (functional) | = 3.1 nM | Cytotoxic activity was measured against human Ovarian carcinoma cell lines | ChEMBL. | 9733497 |
IC50 (functional) | = 3.1 nM | Cytotoxic activity was measured against human Ovarian carcinoma cell lines | ChEMBL. | 9733497 |
IC50 (functional) | > 1.7 uM | Polymerizing activity of tubulin in glutamate against bovine brain tubulin homogenate was measured at 0.4 M concentrations | ChEMBL. | 9733497 |
IC50 (functional) | = 3.1 uM | Polymerizing activity of tubulin in glutamate against bovine brain tubulin homogenate was measured at 0.8M concentrations | ChEMBL. | 9733497 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9733497 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.