Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | microtubule associated protein 2 | 0.0717 | 0.7266 | 0.875 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.078 | 0.1344 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.1421 | 0.1421 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0717 | 0.7266 | 0.7266 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0717 | 0.7266 | 0.875 |
Leishmania major | hypothetical protein, conserved | 0.0231 | 0.1404 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0764 | 0.7833 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0764 | 0.7833 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.1968 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.0943 | 1 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0223 | 0.13 | 0.224 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.5805 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.034 | 0.2719 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.069 | 0.1189 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0596 | 0.5805 | 0.5532 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.034 | 0.2719 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0596 | 0.5805 | 0.5532 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0288 | 0.2094 | 0.2094 |
Loa Loa (eye worm) | ryanodine receptor | 0.0352 | 0.2867 | 0.4938 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 um | PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 629 (Primary screen preceding this dose response confirmation assay.)] | ChEMBL. | No reference |
IC50 (binding) | = 200 uM | The compound was tested for poly(ADP-ribose)polymerase (PARP) inhibition | ChEMBL. | 11689065 |
IC50 (binding) | = 200 uM | The compound was tested for poly(ADP-ribose)polymerase (PARP) inhibition | ChEMBL. | 11689065 |
Log Phep (ADMET) | = -2.34 | Partition coefficient of compound was measured in haptane/water system | ChEMBL. | 8254605 |
log(1/K) (binding) | = -2.6 | Binding affinity to alcohol dehydrogenase (unknown origin) | ChEMBL. | 1246029 |
logP (ADMET) | = 0.96 | Partition coefficient (logP) | ChEMBL. | 8254605 |
logP (ADMET) | = 1 | Partition coefficient (logP) | ChEMBL. | 8254605 |
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.