Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase-like 1 | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative | Get druggable targets OG5_130931 | All targets in OG5_130931 |
Schistosoma japonicum | Putative adenosylhomocysteinase 3, putative | Get druggable targets OG5_130931 | All targets in OG5_130931 |
Schistosoma mansoni | adenosylhomocysteinase | Get druggable targets OG5_130931 | All targets in OG5_130931 |
Schistosoma mansoni | adenosylhomocysteinase | Get druggable targets OG5_130931 | All targets in OG5_130931 |
Schistosoma mansoni | adenosylhomocysteinase | Get druggable targets OG5_130931 | All targets in OG5_130931 |
Schistosoma japonicum | IPR000043,S-adenosyl-L-homocysteine hydrolase,domain-containing | Get druggable targets OG5_130931 | All targets in OG5_130931 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | adenosylhomocysteinase-like 1 | 483 aa | 480 aa | 43.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosylhomocysteinase | 0.0097 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0097 | 0 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0195 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0097 | 0 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0097 | 0 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0097 | 0 | 0.5 |
Brugia malayi | Adenosylhomocysteinase | 0.0097 | 0 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0097 | 0 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0097 | 0 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0097 | 0 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0097 | 0 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0097 | 0 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0097 | 0 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0097 | 0 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0097 | 0 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0097 | 0 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0097 | 0 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0195 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0097 | 0 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0097 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of S-adenosylhomocysteine hydrolase (unknown origin) | ChEMBL. | 26750250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.